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Vanderbilt University Drug Discovery Scientist I in Nashville, Tennessee

Drug Discovery Scientist I (Job Number: 1900745)

Description

The Lab at Vanderbilt University seeks a Drug Discovery Scientist I (DDS I) in medicinal chemistry to join our cancer drug discovery team. As part of the Drug Discovery team, the Scientist will participate in drug discovery efforts by participating in all phases of cancer drug discovery. This includes independently overseeing research; conducting and evaluating experiments and assays; operating and troubleshooting equipment; and developing methods and procedures for operating complex scientific equipment. Develop and interpret Structure Activity Relationships (SAR) and incorporate DMPK into compound design by synthesizing target molecules and interacting with pharmacologist to interpret SAR data. The Scientist will remain abreast of advances in the drug discovery field and appropriately document research studies to include procedures and results of experiments.

The Lab is a multidisciplinary team of structural biologists, medicinal chemists, and cell biologists committed to discovering and developing novel therapeutics for the treatment of cancer. We use fragment-based methods and structure-based design to discover small molecule inhibitors for important oncology targets.

Medicinal chemists in our group have the opportunity to apply cutting edge approaches to drug design and synthesize analogs of hit molecules to improve binding affinity to a protein target and activity in cancer cells and then to optimize the pharmaceutical properties of these molecules.

Duties and responsibilities

D e v e lop a nd i nte r pr e t S t ruc t ure A cti v ity Re l a t i on ship ( S A R ) and inc o rp or a te Drug Me tab o lism a nd Ph a r ma cokinteic (D M PK) i n t o co m p o u n d d e s i g n .

§ Synthesize Target Molecules with minimal supervision

§ Interpret SAR data and interact with pharmacologist

§ Record and Interpret analytical data (LCMS,NMR, etc.)

§ Incorporate DMPK data into ligand design

P a rt i c i p a te in a ll ph a ses of canc e r d rug d iscov e r y .

§ Perform scientific data collection and analyses for research projects requiring independent interpretation of complex research data

§ Conduct and evaluate experiments and assays under moderate supervision

Exerc i se d is c r e t i o n a nd i nd e p e nd e nt j u d gme nt t o d e v e lop me t h o d s a n d proc e d u r e s f or o p e r a t i o n of co m pl e x s c i e nt i fic e qu ip me nt

  • Demonstrateanunderstandingofacceptableproceduresandtechniques

  • Prepare,operate,andtroubleshootequipmentinexperimentalprocedures

K ee p a br ea st of t r e nds i n d rug d iscov e ry f i e ld

  • Remainabreastof theinvitroDMPK/Toxanddrugdiscoveryresearchliterature.

  • Advancethequalityofthroughputofthe invitroDMPK/Toxassaysuite.

Docu me nt p roc e d ur e s u sed a nd r e sul t s o f s t udi e s a s a pp r o p r i a te

  • Provideappropriatewrittendocumentationofexperiments

  • Contributetoresearchastomeritservingas authororco-authoronresearch publications

Profile of an Ideal Candidate

  • ABachelor’sdegreefromanaccreditedinstitution ofhigher educationisnecessary.

  • AMaster’sdegreefromanaccreditedinstitutionofhighereducationispreferred.

  • APh.D.fromanaccredited institutionofhighereducationispreferred.

  • Atleastthreeyearsofexperienceisnecessary.

  • Atleastthreeyearsofexperienceinsyntheticorganicchemistrywithextensivetrainingin syntheticmethodologyand/ortotalsynthesis ispreferred.

  • Experienceinmedicinalchemistry ishighlypreferred.

About Vanderbilt Benefits

Vanderbilt University offers a competitive, flexible benefits package including health, dental, vision, life, accidental death & dismemberment, disability insurance, paid time off, and a 403(b) retirement plan with employer match. Vanderbilt offers tuition assistance to employees, spouses, and dependent children.

About Vanderbilt University

Vanderbilt University, located in Nashville, Tennessee, is a top-15 private research university offering a full range of undergraduate, graduate and professional degrees. Vanderbilt is situated on a 330-acre campus near the thriving city center, serving more than 12,000 students and employing almost 7,000 faculty and staff. The university’s students, staff, and faculty frequently cite Nashville and the surrounding area as one of the many perks of being a part of the Vanderbilt community. Vanderbilt University is a place where your expertise will be valued, your knowledge expanded, and your abilities challenged. It is a place where your diversity is sought and celebrated. Vanderbilt was recently named as one of “America’s Best Large Employers” and the top employer in Tennessee and the Nashville metropolitan area in 2019 (Forbes).

Commitment to Equity, Diversity and Inclusion

Vanderbilt University is committed to achieving the goal of a diverse and inclusive academic community of faculty, staff, and students. We seek individuals who are committed to this goal and our campus values.

Vanderbilt University is an affirmative action, equal opportunity employer and encourages applications from qualified minorities, veterans, and women.

Primary Location: United States-Tennessee-Nashville

Organization: 18220 - Biochemistry

Job: Research, Extension, and Other Education Professionals

Vanderbilt University is committed to principles of equal opportunity and affirmative action

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